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KMID : 0043320190420110962
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Archives of Pharmacal Research
2019 Volume.42 No. 11 p.962 ~ p.976
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Potential molecular mechanisms underlying the effect of arsenic on angiogenesis
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Zhang Juan
Zhang Yue
Wang Weiyan
Zhang Zhiyi
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Abstract
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Arsenic is a potent chemotherapeutic drug that is applied as a treatment for cancer; it exerts its functions through multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progression of many diseases, arsenic is a feasible treatment option for patients with other angiogenic diseases, including rheumatoid arthritis and psoriasis, among others. However, arsenic is also a well-known carcinogen, demonstrating a pro-angiogenesis effect. This review will focus on the dual effects of arsenic on neovascularization and the relevant mechanisms underlying these effects, aiming to provide a rational understanding of arsenic treatment. In particular, we expect to provide a comprehensive overview of the current knowledge of the mechanisms by which arsenic influences angiogenesis.
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KEYWORD
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Arsenic trioxide, Arsenite, Cancer, Angiogenesis, Toxicity
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